In vivo evaluation of the bond strength of adhesive 4-META/MMA-TBB bone cement under weight-bearing conditions

2000 ◽  
Vol 52 (1) ◽  
pp. 128-134 ◽  
Author(s):  
Tomoko Sakai ◽  
Sadao Morita ◽  
Ken-ichi Shinomiya ◽  
Akihiko Watanabe ◽  
Nobuo Nakabayashi ◽  
...  
Keyword(s):  
Bond Strength ◽  
Bone Cement ◽  
Weight Bearing ◽  
In Vivo Evaluation

Development of Novel Bioactive PMMA-Based Bone Cement and its In Vitro and In Vivo Evaluation

2006 ◽  
Vol 309-311 ◽  
pp. 801-804 ◽  
Author(s):  
S.B. Cho ◽  
Akari Takeuchi ◽  
Ill Yong Kim ◽  
Sang Bae Kim ◽  
Chikara Ohtsuki ◽  
...  
Keyword(s):  
Mechanical Property ◽  
Compressive Strength ◽  
Bone Cement ◽  
The Novel ◽  
In Vivo Evaluation ◽  
Natural Bone ◽  
Pmma Bone Cement ◽  
Rabbit Tibia

In order to overcome the disadvantage of commercialized PMMA bone cement, we have developed novel PMMA-based bone cement(7P3S) reinforced by 30 wt.% of bioactive CaO-SiO2 gel powders to induce the bioactivity as well as to increase mechanical property for the PMMA bone cement. The novel 7P3S bone cement hardened after mixing for about 7 minutes. For in vitro evaluation, apatite forming ability of it was investigated using SBF. When the novel 7P3S bone cement was soaked into SBF, it formed apatite on its surfaces within 1 week Furthermore; there is no decrease in its compressive strength within 9 weeks soaking in SBF. It is though that hardly decrease in compressive strength of 7P3S bone cement in SBF is due to the relative small amount of gel powder or its spherical shape and monosize. In vivo evaluation of the novel 7P3S bone cement was carried out using rabbit. After implantion into rabbit tibia for several periods, the interface between novel bone cement and natural bone was evaluated by CT images. According to the results, the novel bone cement directly contact to the natural bone without fibrous tissue after implantation for 4 weeks. This results indicates that the newly developed 7P3S bone cement can bond to the living bone and also be effectively used as bioactive bone cement without decrease in mechanical property.

Development of injectable chitosan/biphasic calcium phosphate bone cement and in vitro and in vivo evaluation

2020 ◽  
Vol 15 (5) ◽  
pp. 055038
Author(s):  
Sirirat T. Rattanachan ◽  
Nuan La-ong Srakaew ◽  
Paritat Thaitalay ◽  
Oranich Thongsri ◽  
Rawee Dangviriyakul ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Bone Cement ◽  
Biphasic Calcium Phosphate ◽  
In Vivo Evaluation ◽  
Calcium Phosphate Bone Cement

scholarly journals In vivo evaluation of bioactive PMMA-based bone cement with unchanged mechanical properties in a load-bearing model on rabbits

2015 ◽  
Vol 30 (1) ◽  
pp. 30-37 ◽  
Author(s):  
Andreas Fottner ◽  
Berthold Nies ◽  
Denis Kitanovic ◽  
Arnd Steinbrück ◽  
Jörg Hausdorf ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Bone Cement ◽  
In Vivo Evaluation ◽  
Load Bearing

Preparation and in vivo evaluation of a silicate-based composite bone cement

2017 ◽  
Vol 32 (2) ◽  
pp. 257-264 ◽  
Author(s):  
Bing Ma ◽  
Zhiguang Huan ◽  
Chen Xu ◽  
Nan Ma ◽  
Haibo Zhu ◽  
...  
Keyword(s):  
Bone Cement ◽  
In Vivo Evaluation ◽  
Composite Bone

scholarly journals Novel bioactive glass based injectable bone cement with improved osteoinductivity and its in vivo evaluation

2017 ◽  
Vol 7 (1) ◽  
Author(s):  
Tengjiao zhu ◽  
Huihui Ren ◽  
Ailing Li ◽  
Bingchuan Liu ◽  
Caiyun cui ◽  
...  
Keyword(s):  
Bioactive Glass ◽  
Bone Cement ◽  
In Vivo Evaluation

scholarly journals In Vitro and In Vivo Evaluation of Vancomycin-Loaded PMMA Cement in Combination with Ultrasound and Microbubbles-Mediated Ultrasound

2015 ◽  
Vol 2015 ◽  
pp. 1-7 ◽  
Author(s):  
Tiao Lin ◽  
Xun-Zi Cai ◽  
Ming-Min Shi ◽  
Zhi-Min Ying ◽  
Bin Hu ◽  
...  
Keyword(s):  
Bone Cement ◽  
Joint Infection ◽  
Study Groups ◽  
In Vivo Evaluation ◽  
Pmma Bone Cement ◽  
Prosthetic Joint ◽  
New Zealand White Rabbits ◽  
Pmma Cement

Ultrasound (US) has been used to increase elution of antibiotic from an antibiotic-loaded poly(methyl methacrylate) (PMMA) bone cement (ALBC). We aimed to further investigate whether microbubbles-mediated US (US + MB) facilitate elution of vancomycin (VAN) from cylindrical specimens and enhance the activity of the eluted antibiotic againstStaphylococcus aureus(S. aureus) in vitro. The study groups comprised cylindrical bone cement fabricated with VAN (VAN), ALBC using US (VAN + US), and ALBC using MB-mediated US (VAN + US + MB). We also carried out an in vivo study involving the activity of VAN from cylindrical cement implanted in tibiae of New Zealand white rabbits inoculated withS. aureus. We found that (1) in vitro, elution from VAN + US + MB cylinders was significantly higher than from either the VAN or VAN + US specimens; (2) the activity of the eluted VAN from the VAN + US + MB cylinders against planktonicS. aureuswas significantly higher than from either the control or VAN or VAN + US specimens; and (3) in the rabbits, the activity of the eluted VAN from the VAN + US + MB cylinders againstS. aureuswas significantly higher than from either the control or VAN or VAN + US specimens. The present results suggest that VAN-loaded PMMA cement irradiated with MB-mediated US may have a role in controlling prosthetic joint infection.

Development of Novel Bioactive PMMA-Based Bone Cement and its In Vitro and In Vivo Evaluation

2006 ◽  
pp. 801-804
Author(s):  
Sung Baek Cho ◽  
Akari Takeuchi ◽  
Ill Yong Kim ◽  
Sang Bae Kim ◽  
Chikara Ohtsuki ◽  
...  
Keyword(s):  
Bone Cement ◽  
In Vivo Evaluation

Bioactive Bone Cement Composed of Crystallized Glass Beads and PMMA: Evaluation of Degradation by an In Vivo Aging Test

2005 ◽  
Vol 284-286 ◽  
pp. 133-136 ◽  
Author(s):  
S. Shinzato ◽  
Takashi Nakamura ◽  
Koji Goto ◽  
Tadashi Kokubo
Keyword(s):  
Molecular Weight ◽  
Bone Cement ◽  
Bending Strength ◽  
Subcutaneous Tissue ◽  
Weight Bearing ◽  
Glass Beads ◽  
Three Point Bending ◽  
Aging Test ◽  
The Difference

A new bioactive bone cement (cGBC) consisting of crystallized MgO-CaO-SiO2-P2O5 glass beads and high-molecular-weight polymethyl methacrylate (hPMMA) has been developed to overcome the degradation seen with a previously reported cement (GBC) consisting of MgO-CaO-SiO2-P2O5-CaF2 glass beads and hPMMA. The purpose of the present study was to evaluate the degradation of cGBC using an in vivo aging test, and to compare the degradation of cGBC with that of GBC. Hardened rectangular specimens (20x4x3mm) were prepared from both cements. Their initial bending strengths were measured using the three-point bending method. GBC and cGBC specimens were then implanted into the dorsal subcutaneous tissue of rats, removed after 6 or 12 months, and tested for bending strength. The initial bending strengths (MPa) of GBC and cGBC were 141.9±1.8 and 144.4±2.4, respectively, while at 6 months they were 109.1±2.6 and 114.1±4.9, and at 12 months they were 109.1±3.2 and 113.1±3.3, respectively. Although the difference in initial bending strengths was not significant, the bending strength of cGBC was significantly higher than that of GBC at 6 and 12 months, indicating that cGBC is more resistant to cement degradation. The bending strengths of both GBC and cGBC decreased significantly from 0 to 6 months but did not change significantly thereafter. Thus, degradation of cGBC and GBC does not appear to continue after 6 months. We believe that cGBC and GBC are strong enough for use under weight-bearing conditions and that their mechanical strength (especially that of cGBC) is retained in vivo.

Segmented interlocking nail: An in vivo evaluation of a novel humeral osteotomy fixation device in a caprine model

2012 ◽  
Vol 25 (01) ◽  
pp. 28-35 ◽  
Author(s):  
R. D. Montgomery ◽  
M. A. Edmondson ◽  
T. J. Stephens
Keyword(s):  
Weight Bearing ◽  
Mature Female ◽  
Bone Union ◽  
Research Model ◽  
Fixation Device ◽  
Insertion Technique ◽  
In Vivo Evaluation ◽  
Interlocking Nail ◽  
Early Return

SummaryObjectives: To describe a novel humeral fixation device, the insertion technique, healing of humeral osteotomies, and clinical outcomes in a caprine model over a six month period.Methods: Fourteen mature female Boer/Nubian cross goats with a mean body weight of 50.7 kg were implanted with a proprietary segmented interlocking nail (SILN) in both humeri. Each goat had one humerus randomly selected for mid-diaphyseal osteotomy.Results: Immediately after surgery all but one goat was able to stand, although none of the goats were weight bearing on the osteotomy limb. During the six month study, clinical lameness was always associated with the osteotomy limb. One month after surgery, lameness for twelve of the goats was grade 2/5 or better. At three months, 11 of the 14 did not exhibit any signs of lameness. On radio-graphic images, notable malalignment of the osteotomy was observed, although all osteotomies went to bone union.Clinical significance: The results of this study suggest that despite misalignment, the SILN maintained adequate osteotomy fixation to achieve bone union in the research model studied, with reduced morbidity and early return to function with bilateral implantation. The SILN used in this study allowed intramedullary fixation of humeral diaphyseal osteotomies with a limited and safe surgical approach.

scholarly journals Pre-contrast T1 and cartilage thickness as confounding factors in dGEMRIC when evaluating human cartilage adaptation to physical activity

2019 ◽  
Vol 20 (1) ◽  
Author(s):  
Carl Johan Tiderius ◽  
Zana K. Hawezi ◽  
Lars E. Olsson ◽  
Leif E. Dahlberg
Keyword(s):  
Weight Bearing ◽  
Cartilage Thickness ◽  
T1 Relaxation Time ◽  
In Vivo Evaluation ◽  
Human Cartilage ◽  
Gadolinium Concentration ◽  
T1 Relaxation ◽  
Sedentary Group ◽  
And Cartilage

Abstract Background The dGEMRIC (delayed Gadolinium-Enhanced MRI of Cartilage) technique has been used in numerous studies for quantitative in vivo evaluation of the relative glycosaminoglycan (GAG) content in cartilage. The purpose of this study was to determine the influence of pre-contrast T1 and cartilage thickness when assessing knee joint cartilage quality with dGEMRIC. Methods Cartilage thickness and T1 relaxation time were measured in the central part of the femoral condyles before and two hours after intravenous Gd-DTPA2− administration in 17 healthy volunteers from a previous study divided into two groups: 9 sedentary volunteers and 8 exercising elite runners. Results were analyzed in superficial and a deep weight-bearing, as well as in non-weight-bearing regions of interest. Results In the medial compartment, the cartilage was thicker in the exercising group, in weight-bearing and non-weight-bearing segments. In most of the segments, the T1 pre-contrast value was longer in the exercising group compared to the sedentary group. Both groups had a longer pre-contrast T1 in the superficial cartilage than in the deep cartilage. In the superficial cartilage, the gadolinium concentration was independent of cartilage thickness. In contrast, there was a linear correlation between the gadolinium concentration and cartilage thickness in the deep cartilage region. Conclusion Cartilage pre-contrast T1 and thickness are sources of error in dGEMRIC that should be considered when analysing bulk values. Our results indicate that differences in cartilage structure due to exercise and weight-bearing may be less pronounced than previously demonstrated.

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